Related Experiment Video
Updated: Aug 9, 2025
08:54
An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells
Published on: July 20, 2014
14.1K
Eph Receptors in Cancer.
Sakshi Arora1, Andrew M Scott1, Peter W Janes1
1Olivia Newton-John Cancer Research Institute, School of Cancer Medicine, La Trobe University, Heidelberg, VIC 3084, Australia.
Biomedicines
|February 25, 2023
Summary
Eph receptor tyrosine kinases and their ligands, ephrins, are crucial in development and cancer. Understanding their dual roles as promoters or suppressors is key for developing targeted cancer therapies.
Area of Science:
- Molecular Biology
- Cell Biology
- Oncology
Background:
- Eph receptor tyrosine kinases (Ephs) and ephrins are vital for tissue development and homeostasis.
- Their dysregulation and overexpression in cancers link them to tumor progression, angiogenesis, and invasion.
- Mutations in Ephs are implicated in tumorigenesis, highlighting their complex role in cancer.
Purpose of the Study:
- To review the diverse roles of Ephs and ephrins in various malignancies.
- To explore the impact of Ephs on tumor cell behavior and development.
- To discuss current therapeutic strategies targeting Ephs in cancer treatment.
Main Methods:
- Literature review of Eph and ephrin expression and function in cancer.
- Analysis of in vitro and in vivo studies on Eph-mediated effects on tumor cells.
- Examination of preclinical and clinical data on Eph-targeted therapies.
Main Results:
- Eph expression varies across different cancer types, acting as both tumor promoters and suppressors.
- Ephs influence tumor cell proliferation, migration, invasion, angiogenesis, and metastasis.
- Targeting Ephs presents a promising, yet complex, therapeutic avenue.
Conclusions:
- Eph signaling pathways are critical regulators in cancer, with context-dependent functions.
- Further research into the opposing roles of Ephs is essential for effective cancer therapy development.
- Targeting Ephs offers potential for novel cancer treatments, requiring careful consideration of their multifaceted roles.
More Related Videos
09:53Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
Published on: February 6, 2017
11.5K
15:05Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
Published on: May 20, 2020
8.7K
Related Concept Videos
02:38Mitogens and the Cell Cycle
6.6K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.6K
01:22Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.3K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.3K
01:15Receptor Downregulation in MVBs
2.1K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
2.1K
01:27Transducer Mechanism: Enzyme-Linked Receptors
2.6K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
2.6K
02:30Metastasis
5.6K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.6K
01:25Selectins
3.4K
Cell adhesion is an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
3.4K