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Protein Kinase CK2 and Epstein-Barr Virus

Mathias Montenarh1, Friedrich A Grässer2, Claudia Götz1

  • 1Medical Biochemistry and Molecular Biology, Saarland University, Buildings 44 and 47, 66424 Homburg, Germany.

Biomedicines
|February 25, 2023
PubMed

Insights

Protein kinase CK2 phosphorylates Epstein-Barr virus (EBV) proteins and host factors, driving viral replication and cancer. Inhibiting CK2 kinase activity offers a potential strategy against EBV infection and EBV-induced tumors.

Area of Science:

  • Molecular Biology
  • Virology
  • Oncology

Background:

  • Protein kinase CK2 is a key regulator of numerous cellular processes, including proliferation, apoptosis, and immune response.
  • Viruses leverage host cell machinery for replication and transformation, often involving host kinases.
  • Epstein-Barr virus (EBV) is linked to various cancers, such as Burkitt's lymphoma, and its interaction with CK2 has been known since the early 1990s.

Purpose of the Study:

  • To review the role of protein kinase CK2 in Epstein-Barr virus (EBV) infection and EBV-induced neoplastic transformation.
  • To elucidate how CK2-mediated phosphorylation of viral and cellular proteins contributes to viral replication and cancer development.

Main Methods:

  • Literature review of studies investigating the interaction between CK2 and EBV.
  • Analysis of the phosphorylation targets of CK2 within the context of EBV infection and transformation.
  • Examination of the functional consequences of CK2 activity on viral and cellular proteins.

Main Results:

  • CK2 phosphorylates both EBV-encoded proteins and host cellular proteins crucial for viral lytic and persistent infections.
  • CK2-mediated phosphorylation of viral and cellular proteins facilitates efficient EBV replication and neoplastic transformation.
  • EBV-encoded proteins and CK2-phosphorylated cellular signaling proteins contribute to oncogenesis.

Conclusions:

  • Protein kinase CK2 plays a significant role in EBV replication and the development of EBV-associated cancers.
  • CK2 is a potential therapeutic target for inhibiting EBV replication and preventing EBV-induced cell transformation.
  • Targeting CK2 kinase activity may offer a novel strategy for treating EBV-related malignancies.
Keywords:
EBV-encoded proteinsEpstein–Barr virusp53phosphorylationprotein kinase CK2reviewsignaling pathways

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