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Extracellular Vesicles in Aging: An Emerging Hallmark?

Giorgia Manni1, Sandra Buratta2, Maria Teresa Pallotta1

  • 1Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy.

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|February 25, 2023
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Summary

Extracellular vesicles (EVs) are increasingly recognized for their role in cell signaling and aging. Altered EV release is linked to aging, with EVs showing potential for anti-aging therapies.

Keywords:
agingextracellular vesicles (EVs)senescencesenescence-associated secretory phenotype (SASP)

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Area of Science:

  • Cell Biology
  • Gerontology
  • Biochemistry

Background:

  • Extracellular vesicles (EVs) are cell-secreted particles involved in intercellular communication.
  • Aging is marked by physiological decline and is associated with hallmarks like genomic instability and epigenetic alterations.
  • Recent research links cellular stress and aging to increased EV release, potentially spreading senescence signals.

Purpose of the Study:

  • To review the current literature on EV secretion in aging.
  • To explore the role of EVs in senescent cell models and body fluids of young versus old individuals.
  • To assess the potential of EVs as an anti-aging therapeutic tool.

Main Methods:

  • Literature review of studies on EV secretion in senescent cells.
  • Analysis of studies comparing EV release in young versus old individuals.
  • Examination of research on EV-based anti-aging strategies.

Main Results:

  • Increased EV release is observed in senescent cell models.
  • Altered EV secretion patterns are detected in body fluids of older individuals.
  • EVs demonstrate potential for modulating age-related phenotypes and developing rejuvenation therapies.

Conclusions:

  • Altered extracellular vesicle secretion is emerging as a hallmark of aging.
  • EVs represent a promising avenue for future anti-aging interventions and therapies for age-related diseases.