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Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Non-Canonical Wnt Signaling Pathways01:41

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Chronic Pancreatitis I: Introduction01:24

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

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Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
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Notch Signaling Pathway03:14

Notch Signaling Pathway

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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Wnt Pathway in Pancreatic Development and Pathophysiology.

Tiziana Napolitano1, Serena Silvano1, Chaïma Ayachi2

  • 1DiogenX, 180 Avenue du Prado, 13008 Marseille, France.

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|February 25, 2023
PubMed
Summary
This summary is machine-generated.

The Wnt/β-catenin pathway is crucial for pancreas development and function. Understanding its role may lead to new therapies for pancreatic diseases.

Keywords:
Wnt pathwaydiabetesembryonic developmentpancreasβ-cateninβ-cells

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Area of Science:

  • Developmental Biology
  • Endocrinology
  • Molecular Signaling

Background:

  • The pancreas performs digestive and endocrine functions, originating from foregut endoderm during embryonic development.
  • Pancreatic cell development involves complex signaling pathways.
  • The Wnt/β-catenin pathway is increasingly recognized for its role in pancreas organogenesis.

Purpose of the Study:

  • To review the role of Wnt/β-catenin signaling in pancreas biology.
  • To highlight its significance in pancreatic development and adult cell function.
  • To emphasize its therapeutic potential for pancreatic diseases.

Main Methods:

  • Literature review of recent research on Wnt/β-catenin signaling in pancreas biology.
  • Analysis of studies covering embryonic development to adulthood.
  • Focus on implications for therapeutic development.

Main Results:

  • Wnt/β-catenin signaling regulates pancreatic epithelium specification, compartmentalization, and expansion during organogenesis.
  • This pathway influences the proliferation, survival, and function of adult pancreatic cells, including beta cells.
  • Recent findings underscore its multifaceted role throughout pancreatic life.

Conclusions:

  • Wnt/β-catenin signaling is a key regulator in pancreas development and maintenance.
  • Targeting this pathway holds promise for novel therapeutic strategies for various pancreatic diseases.
  • Further research is warranted to fully elucidate its therapeutic applications.