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Updated: Aug 9, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

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Mitochondrial Lipid Peroxidation Is Responsible for Ferroptosis

Konstantin G Lyamzaev1,2, Alisa A Panteleeva1, Ruben A Simonyan1

  • 1Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.

Cells
|February 25, 2023
PubMed
Summary

Mitochondria-targeted antioxidants and methylene blue prevent ferroptosis by inhibiting mitochondrial lipid peroxidation. Reactive oxygen species (ROS) generated in mitochondrial complex I promote this process, suggesting a key role in cell death.

Keywords:
complex Iferroptosismitochondriamitochondria targeted antioxidantsmtROS

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