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Peroxisome Proliferator-Activated Receptor-Targeted Therapies: Challenges upon Infectious Diseases

In Soo Kim1,2,3, Prashanta Silwal4, Eun-Kyeong Jo1,2,3

  • 1Department of Microbiology, College of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea.

Cells
|February 25, 2023
PubMed

Insights

Peroxisome proliferator-activated receptors (PPARs) regulate energy, inflammation, and development. This review explores how PPARs impact infectious diseases and their therapeutic potential.

Area of Science:

  • Molecular Biology
  • Immunology
  • Pharmacology

Background:

  • Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors regulating diverse biological processes.
  • PPARs are implicated in energy metabolism, inflammation, cellular development, and differentiation.
  • Dysregulation of PPARs is linked to metabolic diseases, inflammation, and cancer.

Purpose of the Study:

  • To review recent research on the role of PPARs in infectious diseases.
  • To explore how PPARs modulate host-pathogen interactions and immune responses.
  • To discuss the therapeutic potential of PPAR modulators in treating infections.

Main Methods:

  • Literature review of recent studies on PPARs and infectious diseases.
  • Analysis of experimental data on PPAR function in host-pathogen interactions.
  • Synthesis of information on the clinical applications of PPAR agonists and antagonists.

Main Results:

  • PPARs play distinct roles in the pathogenesis of viral, bacterial, and parasitic infections.
  • PPAR signaling influences immune cell function and inflammatory responses during infection.
  • Evidence suggests PPARs are critical regulators of host defense mechanisms.

Conclusions:

  • Understanding PPARs' role in host-pathogen interactions is crucial for developing new therapies.
  • PPAR agonists/antagonists represent promising adjunctive treatments for infectious diseases.
  • Personalized therapies targeting PPAR pathways could enhance treatment outcomes for various infections.
Keywords:
bacteriainfectionparasiteperoxisome proliferator-activated receptorvirus

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