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A Wrong Fate Decision in Adipose Stem Cells upon Obesity
Yiu-Ming Cheung1, Chui-Yiu-Bamboo Chook1, Hoi-Wa Yeung1
1School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Cells
|February 25, 2023
Summary
Stem cell aging contributes to obesity by impairing adipogenesis in adipose stem cells (ASCs). Reversing this aging process offers a potential anti-obesity treatment strategy.
Area of Science:
- Cellular biology
- Metabolic diseases
- Stem cell research
Background:
- Stem cell aging is implicated in various diseases, including obesity.
- Adipose stem cells (ASCs) are crucial for maintaining adipose tissue homeostasis through adipocyte turnover.
- Aberrant lineage determination in aging stem cells contributes to impaired adipogenesis.
Purpose of the Study:
- To review the mechanisms by which ASCs fail to undergo adipogenesis.
- To explore potential therapeutic strategies targeting ASCs for obesity treatment.
Main Methods:
- Review of current literature on stem cell aging and obesity.
- Focus on extracellular signaling, epigenetic changes, metabolic reprogramming, and mechanical factors affecting ASCs.
Main Results:
- Aging ASCs exhibit impaired adipogenesis, leading to adipose tissue hypertrophy (adiposopathy) and related complications.
- Detrimental alterations in ASCs can be reversed by promoting adipogenesis.
Conclusions:
- Targeting adipogenesis is a promising therapeutic strategy for obesity.
- Rejuvenating tissue stem cells may alleviate metabolic syndrome by addressing ASC aging.
