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Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

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Distinguishing Curable from Progressive Dementias for Defining Cancer Care Options.

Catherine H Schein¹

¹Department of Biochemistry and Molecular Biology, Institute for Human Infections and Immunity, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.

|February 25, 2023

Summary

This summary is machine-generated.

Age-related dementia, delirium, and depression can mimic neurodegenerative diseases. Early detection and personalized treatments, including immunotherapies and genetic profiling, offer hope for reversal and cure.

Keywords:

Alzheimer & Parkinson diseases PIMs (potentially inappropriate medications)autoimmune encephalitis cancer care team cancer genetic profiling conditions causing altered mental state de-prescribing dementia, delirium, depression (3Ds)immunotherapy in CRC microsatellite instability (MSI/DNA mismatch repair (dMMR)neurological syndromes non-surgical intervention in frail patients polypharmacy

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Area of Science:

Gerontology
Neurology
Oncology

Background:

Dementia risk increases with age, similar to cancers like melanoma and multiple myeloma.
Dementia patients often miss cancer treatment opportunities due to diagnostic challenges.
Neurological symptoms can stem from various factors beyond neurodegeneration, including lifestyle and medications.

Purpose of the Study:

To explore the complex interplay between aging, neurological symptoms, and cancer.
To highlight the potential for reversing or managing dementia-like syndromes.
To advocate for comprehensive diagnostic approaches and personalized treatments.

Main Methods:

Analysis of diet and medication history.
Advanced imaging techniques.
Genetic profiling for personalized treatment strategies.
Identification of paraneoplastic neurological syndromes.

Main Results:

Conditions like cachexia, malnutrition, dehydration, alcohol use, and loneliness can exacerbate or cause dementia, delirium, and depression.
Polypharmacy can lead to cognitive impairment resembling neurodegenerative diseases.
Immune responses to autoantigens, sometimes cancer-related, can mimic Alzheimer's and Parkinson's diseases.
Paraneoplastic neurological syndromes are treatable with immunotherapy or tumor removal if caught early.

Conclusions:

Reversible causes of dementia-like symptoms exist and can be managed through lifestyle changes and medication review.
Genetic profiling is crucial for guiding tailored, less invasive cancer treatments in elderly or frail patients.
Early detection of paraneoplastic syndromes and prompt treatment, including tumor removal or immunotherapy, can improve outcomes.