Related Experiment Video
Updated: Aug 9, 2025
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
Prognostic Factors in Pseudomyxoma Peritonei with Emphasis on the Predictive Role of Peritoneal Cancer Index and
Sebastian Blaj1, David Dora2, Zoltan Lohinai3,4
1Department of General and Visceral Surgery, Hospital Barmherzige Brüder, D-93049 Regensburg, Germany.
Background:
Pseudomyxoma peritonei (PMP) is a rare peritoneal condition where mucus-secreting tumorous cells progressively produce a thick, gelatin-like substance. The prognosis of patients with PMP is determined by the degree of cellularity within the mucin (low-grade (LAMN) vs. high-grade (HAMN) histologic features) and by the extent of the disease.
Methods:
Prognostic relevance of tumor markers CA19-9 and CEA, gender, Peritoneal Cancer Index (PCI), and completeness of cytoreduction (CC) after cytoreductive surgery were evaluated on 193 consecutive PMP patients, based on a retrospective analysis of prospectively gathered data from a German tertial referral center.
Results:
We demonstrated that low PCI, CC0 status, low-grade histology, and female gender were independent positive prognostic factors for both overall survival (OS) and progression-free survival (PFS). Furthermore, LAMN patients with achieved CC0 status show significantly better OS and PFS compared to those with CC1 status (p = 0.0353 and p = 0.0026 respectively). In contrast, the duration and drug of hyperthermic intraperitoneal chemotherapy (HIPEC) were not prognostic in any comparison. Increased CA19-9 and CEA levels were significantly associated with HAMN cases, but also predicted recurrence in patients with low-grade histologies.
Conclusion:
Our study confirmed the prognostic role of tumor markers and emphasized the importance of CC status and PCI in a large cohort of PMP- and LAMN patients.
Insights
Pseudomyxoma peritonei (PMP) prognosis is improved by low Peritoneal Cancer Index (PCI) and complete cytoreduction (CC0). Female gender and low-grade histology (LAMN) also positively impact survival in PMP patients.
Area of Science:
- Oncology
- Surgical Oncology
Background:
- Pseudomyxoma peritonei (PMP) is a rare condition characterized by mucin-producing tumor cells in the peritoneum.
- Prognosis in PMP depends on tumor grade (low-grade (LAMN) vs. high-grade (HAMN)) and disease extent.
Purpose of the Study:
- To evaluate prognostic factors for overall survival (OS) and progression-free survival (PFS) in Pseudomyxoma peritonei (PMP) patients.
- To assess the role of tumor markers, patient demographics, and surgical outcomes in PMP.
Main Methods:
- Retrospective analysis of prospectively gathered data from 193 consecutive PMP patients.
- Evaluation of tumor markers (CA19-9, CEA), gender, Peritoneal Cancer Index (PCI), and completeness of cytoreduction (CC).
Main Results:
- Low PCI, CC0 status, low-grade histology (LAMN), and female gender were independent positive prognostic factors for OS and PFS.
- LAMN patients achieving CC0 status demonstrated significantly better OS and PFS than those with CC1.
- Hyperthermic intraperitoneal chemotherapy (HIPEC) duration and drug were not prognostic; elevated CA19-9/CEA predicted recurrence in LAMN and were associated with HAMN.
Conclusions:
- The study confirms the prognostic significance of tumor markers, completeness of cytoreduction (CC), and Peritoneal Cancer Index (PCI) in PMP.
- Achieving complete cytoreduction (CC0) is crucial for improved outcomes, particularly in low-grade mucinous adenocarcinoma (LAMN) cases.
More Related Videos
10:28Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
09:19Culture and Imaging of Ex Vivo Organotypic Pseudomyxoma Peritonei Tumor Slices from Resected Human Tumor Specimens
Published on: December 9, 2022
