Cognitive Reserve in Isolated Rapid Eye-Movement Sleep Behavior Disorder.
Giada D'Este1,2, Francesca Berra1,2, Giulia Carli3
1Department of Psychology, "Vita-Salute" San Raffaele University, 20132 Milan, Italy.
Brain Sciences
|February 25, 2023
Summary
Cognitive reserve may protect against cognitive decline in isolated rapid-eye-movement sleep behaviour disorder (iRBD). Higher cognitive reserve in iRBD patients is linked to better cognitive function and less impairment.
Area of Science:
- Neurology
- Sleep Medicine
- Cognitive Neuroscience
Background:
- Isolated rapid-eye-movement sleep behaviour disorder (iRBD) is a prodromal stage of α-synucleinopathies.
- Progression timing in iRBD patients varies significantly (5-15 years).
- Cognitive reserve (CR) is a potential factor influencing cognitive decline in neurodegenerative diseases.
Purpose of the Study:
- To investigate the impact of cognitive reserve (CR) on cognitive performance in polysomnography-confirmed iRBD patients.
- To explore CR as a potential protective factor against cognitive decline in iRBD.
Main Methods:
- Fifty-five iRBD patients underwent clinical and neuropsychological evaluations.
- Cognitive reserve was assessed using the CR Index questionnaire.
- Cognitive performance was evaluated at diagnosis.
Main Results:
- iRBD patients with high CR levels exhibited a lower prevalence of mild cognitive impairment (10%).
- High CR was associated with superior performance in visuo-constructive and verbal memory tasks.
- Specifically, better recall of the Rey-Osterrieth complex figure test was observed in high CR individuals.
Conclusions:
- Cognitive reserve may help iRBD patients mitigate cognitive decline associated with neurodegeneration.
- CR shows potential as a protective factor in iRBD.
- Further longitudinal studies are warranted to confirm CR's role in iRBD conversion and cognitive deterioration timing.
Keywords:
Cognitive Reserve Index questionnaireRBDcognitive reserveneurodegenerative disordersneuropsychological evaluationneuropsychologyrapid-eye-movement sleep behaviour disordersleep disordersα-synucleinopathiesMore Related Videos
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