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Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

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Altered Feedback-Related Negativity in Mild Cognitive Impairment.

Satoshi Abe¹, Keiichi Onoda², Masahiro Takamura¹

¹Department of Neurology, Faculty of Medicine, Shimane University, Izumo, Shimane 693-8501, Japan.

|February 25, 2023

Summary

Mild cognitive impairment (MCI) patients exhibit altered brain activity, specifically increased feedback-related negativity (FRN) amplitude, suggesting monitoring dysfunction in early dementia stages.

Keywords:

event-related brain potentials feedback-related negativity mild cognitive impairment

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Area of Science:

Neuroscience
Cognitive Science
Neurology

Background:

Feedback-related negativity (FRN) is brain activity crucial for monitoring behavior and outcomes.
Previous research indicated altered FRN in Alzheimer's disease (AD).
Mild cognitive impairment (MCI) is a precursor to AD, suggesting potential FRN changes.

Purpose of the Study:

To investigate alterations in FRN in individuals with MCI.
To examine FRN changes during a gambling task in MCI patients.

Main Methods:

Thirteen MCI patients and 13 healthy elderly controls performed a gambling task.
Electroencephalography (EEG) recorded brain activity, with FRN derived from feedback responses.
Neuro-psychological assessments were conducted.

Main Results:

MCI patients showed significantly larger FRN amplitude compared to controls.
No significant difference in FRN latency was observed between groups.
Increased FRN amplitude correlated with cognitive scores (MMSE).

Conclusions:

Monitoring dysfunction is implicated in the prodromal stage of dementia.
Altered FRN in MCI aligns with findings in mild AD.
FRN may serve as a biomarker for early dementia detection.