The Peripheral Immune Traits Changed in Patients with Multiple System Atrophy

A growing body of evidence suggests immune involvement in the pathology of multiple system atrophy (MSA). Research on detailed peripheral immune indices, however, is relatively sparse, and is one of the intriguing aspects of MSA yet to be elucidated. A total of 26 MSA patients and 56 age-and sex-matched healthy controls (HC) were enrolled in the current case-control study to delineate the peripheral immune traits of MSA patients. The ratio of CD4⁺/CD8⁺ T cells, natural killer cells, CD28 expression on both CD4⁺ T cells and CD8⁺ T cells increased in MSA patients compared to HC, but CD8⁺ T cells and active marker (HLA-DR) expression on total T cells decreased (p < 0.05). This study sheds light on the dysregulation of cellular immunity in MSA, pointing to future mechanistic research.