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Real-Time Ellipsometric Surface Plasmon Resonance Sensor Using Polarization Camera May Provide the Ultimate Detection
Nipun Vashistha1, Marwan J Abuleil1, Anand M Shrivastav1
1Department of Electro-Optic Engineering, Ilse-Katz Institute for Nanoscale Science and Technology, Ben Gurion University, Beer Sheva 84105, Israel.
Biosensors
|February 25, 2023
Summary
This study introduces a novel ellipsometric Surface Plasmon Resonance (SPR) sensor for real-time, high-precision biological detection. The new method achieves superior stability and a potential ultimate detection limit for SPR sensors.
Area of Science:
- Optoelectronics
- Biosensing
- Surface Chemistry
Background:
- Ellipsometric Surface Plasmon Resonance (SPR) sensors offer simpler optical setups than interferometric or heterodyne methods.
- Existing intensity-based ellipsometric SPR sensors face limitations in real-time applications due to serial phase/polarization shifts.
Purpose of the Study:
- To develop a real-time, high-precision ellipsometric SPR sensor.
- To overcome the limitations of serial measurements in current ellipsometric SPR sensors.
Main Methods:
- Utilized a Kretschmann-Raether (KR) diverging beam configuration.
- Employed a pixelated microgrid polarization camera for simultaneous data acquisition.
- Measured ellipsometric parameters tanψ and cos(Δ) for enhanced stability.
Main Results:
- Demonstrated superior short-term stability compared to direct SPR or intensity measurements, especially with fluctuating laser sources.
- Achieved real-time refractive index and dynamic change measurements.
- Showcased sub-nM to pM resolution in Bovine Serum Albumin (BSA)-anti-BSA antibody binding assays.
Conclusions:
- The developed ellipsometric SPR sensor enables real-time, high-precision biological sensing.
- The methodology offers improved stability and a potential for ultimate detection limits in SPR sensing.
- This approach holds significant promise for advancing biosensing applications.
