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Cortisol Immunosensors: A Literature Review
Chrysoula-Evangelia Karachaliou1, Georgios Koukouvinos2, Dimitrios Goustouridis3,4
1Immunopeptide Chemistry Lab., Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Centre for Scientific Research ''Demokritos", P.O. Box 60037, 153 10 Agia Paraskevi, Greece.
Biosensors
|February 25, 2023
Summary
Cortisol determination is crucial for diagnosing stress and related diseases. This review highlights advances in cortisol immunosensors, offering potential for real-time, point-of-care monitoring beyond traditional immunoassays.
Area of Science:
- Biochemistry
- Analytical Chemistry
- Biomedical Engineering
Background:
- Cortisol is a vital steroid hormone and biomarker for stress and related diseases.
- Accurate cortisol measurement in biological samples (serum, saliva, urine) holds significant clinical value.
- Conventional immunoassays (RIAs, ELISAs) are the gold standard but have limitations.
Purpose of the Study:
- To review recent advancements in cortisol immunosensors.
- To present the principles behind electrochemical and optical cortisol immunosensing.
- To discuss future prospects for immunosensor technology in cortisol analysis.
Main Methods:
- Review of reported cortisol immunosensors, focusing on electrochemical and optical types.
- Analysis of immunosensing and detection principles.
- Discussion of potential applications and future research directions.
Main Results:
- Cortisol immunosensors offer potential for real-time, point-of-care analysis.
- Wearable electrochemical sensors show promise for continuous cortisol monitoring (e.g., in sweat).
- Immunosensors may overcome limitations of conventional immunoassays.
Conclusions:
- Cortisol immunosensors represent a promising next generation of analytical tools.
- Further development could lead to improved diagnostics and continuous health monitoring.
- The field is advancing towards more accessible and efficient cortisol detection methods.
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