Related Experiment Video

Updated: Aug 9, 2025

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
12:24

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

10.0K

Cardiovascular Magnetic Resonance Imaging Findings in Africans with Idiopathic Dilated Cardiomyopathy

Nqoba Tsabedze1, Andre du Plessis2, Dineo Mpanya1

  • 1Division of Cardiology, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.

Diagnostics (Basel, Switzerland)
|February 25, 2023
PubMed

Insights

Idiopathic dilated cardiomyopathy (IDCM) in sub-Saharan Africa is a significant cause of heart failure. Cardiovascular magnetic resonance (CMR) imaging reveals that late gadolinium enhancement (LGE) is a key predictor of mortality in these patients.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Genetics

Background:

  • Idiopathic dilated cardiomyopathy (IDCM) is a prevalent cause of heart failure in sub-Saharan Africa, yet it remains understudied.
  • Cardiovascular magnetic resonance (CMR) imaging is the established standard for assessing heart muscle characteristics and volume.
  • This study investigates CMR findings in Southern African patients with IDCM, focusing on potential genetic underpinnings.

Purpose of the Study:

  • To characterize Cardiovascular magnetic resonance (CMR) findings in a cohort of patients with idiopathic dilated cardiomyopathy (IDCM) in Southern Africa.
  • To explore the association between CMR parameters and patient outcomes, including mortality.
  • To identify potential genetic causes contributing to IDCM in this population.

Main Methods:

  • Seventy-eight patients with suspected genetic IDCM underwent CMR imaging.
  • Key metrics assessed included left ventricular ejection fraction, left ventricular end-diastolic wall mass index, and right ventricular end-systolic volume index.
  • Late gadolinium enhancement (LGE) patterns were analyzed, with a focus on midwall localization.

Main Results:

  • The median left ventricular ejection fraction was 24%.
  • Late gadolinium enhancement (LGE) was present in 55.1% of participants, commonly in the midwall (65.0%).
  • Non-survivors exhibited significantly higher left ventricular end-diastolic wall mass index and right ventricular end-systolic volume index compared to survivors. The hazard ratio for death in patients with LGE was 0.435 (p=0.002).

Conclusions:

  • Cardiovascular magnetic resonance (CMR) imaging, particularly the presence of late gadolinium enhancement (LGE), is a significant prognostic indicator for mortality in sub-Saharan African patients with idiopathic dilated cardiomyopathy (IDCM).
  • Further large-scale, multi-center studies are needed across sub-Saharan Africa to fully elucidate the prognostic value of various CMR parameters, including LGE, extracellular volume fraction, and strain patterns, in African IDCM cohorts.

Keywords:
all-cause mortalitycardiovascularidiopathic dilated cardiomyopathylate gadolinium enhancementmagnetic resonance imaging

More Related Videos

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

1.7K
Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging11:13

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

Published on: May 24, 2021

6.5K

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
15
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
73
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
21
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
41
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
15
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
29