Related Experiment Video

Updated: Aug 9, 2025

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
08:16

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

Published on: March 16, 2022

3.6K

Symptomatic Popliteal Artery Aneurysms in Recently SARS-CoV-2-Infected Patients: The Microangiopathic Thrombosis That

Laura Capoccia1, Wassim Mansour2, Luca di Marzo2

  • 1Department of Surgery, Vascular Surgery Division, SS Filippo e Nicola Hospital, 67051 Avezzano, Italy.

Diagnostics (Basel, Switzerland)
|February 25, 2023
PubMed
Abstract

Insights

COVID-19 infection significantly increases the risk of symptomatic popliteal artery aneurysms (PAA) and complications following urgent revascularization surgery. This highlights the importance of considering recent or ongoing SARS-CoV-2 infection in PAA patients.

Area of Science:

  • Vascular Surgery
  • Infectious Diseases
  • Thrombosis

Background:

  • SARS-CoV-2 infection is linked to arterial and venous thrombosis.
  • Microangiopathic thrombosis can negatively impact urgent limb revascularization outcomes.
  • Popliteal artery aneurysms (PAA) are susceptible to thrombotic complications.

Purpose of the Study:

  • To determine the incidence of symptom development in patients with PAA.
  • To analyze the impact of COVID-19 infection on PAA patient outcomes.
  • To investigate the association between COVID-19 and PAA-related symptoms and surgical results.

Main Methods:

  • Prospective data collection from PAA patients surgically treated between March 2021 and March 2022.
  • Analysis of factors including symptom presence, aneurysm characteristics, referral time, and COVID-19 status.
  • Evaluation of outcomes such as death, amputation, and neurological deficit.

Main Results:

  • Fifteen of 35 surgically treated PAA patients presented with symptoms requiring urgent intervention.
  • Nine of these 15 symptomatic patients had recent or ongoing COVID-19 infection.
  • COVID-19 infection showed a strong association with symptom development (OR 40) and surgical failure in PAA patients.

Conclusions:

  • COVID-19 infection is significantly associated with the onset of ischemic symptoms in PAA patients.
  • COVID-19 is linked to increased complications after urgent surgical treatment for symptomatic PAA.
  • Consideration of SARS-CoV-2 status is crucial for managing PAA patients.
Keywords:
COVID-19endovascular treatmentfemoro-popliteal bypasspopliteal artery aneurysmthrombosis

More Related Videos

A New Murine Model of Endovascular Aortic Aneurysm Repair08:51

A New Murine Model of Endovascular Aortic Aneurysm Repair

Published on: July 7, 2013

14.4K
Arterial Pouch Microsurgical Bifurcation Aneurysm Model in the Rabbit06:11

Arterial Pouch Microsurgical Bifurcation Aneurysm Model in the Rabbit

Published on: May 14, 2020

2.4K

Related Concept Videos

Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
16
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
22
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs but also impacts other areas, such as the arms, thereby impairing overall circulation and organ function.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty deposits inside the arterial...
14
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
16
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
16
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
21