Related Experiment Video

Updated: Aug 9, 2025

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice
09:09

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice

Published on: August 9, 2013

39.9K

Association between Urinary Creatinine Excretion and Hypothyroidism in Patients with Chronic Kidney Disease

Natsumi Matsuoka-Uchiyama1, Kenji Tsuji1, Kensaku Takahashi1

  • 1Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.

Diagnostics (Basel, Switzerland)
|February 25, 2023
PubMed

Insights

Hypothyroidism does not independently affect urinary creatinine excretion rate (CER) in chronic kidney disease patients. Estimated glomerular filtration rate (eGFR) remains a reliable kidney function marker, irrespective of thyroid status.

Area of Science:

  • Nephrology
  • Endocrinology
  • Biochemistry

Background:

  • Hypothyroidism is known to increase serum creatinine (Cr) levels.
  • The precise mechanism, whether decreased glomerular filtration rate (GFR) or increased muscle Cr production, remains unclear.
  • Understanding Cr metabolism in hypothyroidism is crucial for accurate kidney function assessment.

Purpose of the Study:

  • To investigate the association between hypothyroidism and urinary creatinine excretion rate (CER) in patients with chronic kidney disease (CKD).
  • To determine if hypothyroidism independently influences urinary CER.
  • To evaluate the utility of estimated GFR (eGFR) as a kidney function marker in hypothyroid patients.

Main Methods:

  • Cross-sectional study involving 553 CKD patients.
  • Multiple linear regression analysis to assess the relationship between hypothyroidism and urinary CER.
  • Scatter plot analysis to compare estimated GFR (eGFRcre) with 24-hour Cr clearance (24hrCcr).

Main Results:

  • The mean urinary CER was 1.01 ± 0.38 g/day; 22% of patients had hypothyroidism.
  • Hypothyroidism was not identified as an independent explanatory variable for urinary CER.
  • Strong correlations were observed between eGFRcre and 24hrCcr in both hypothyroid and euthyroid groups.

Conclusions:

  • Hypothyroidism is not an independent predictor of urinary creatinine excretion rate in CKD patients.
  • Estimated GFR calculated using serum creatinine is a reliable indicator of kidney function, even in the presence of hypothyroidism.
  • This finding supports the continued use of eGFR for monitoring kidney health across different thyroid statuses.

Keywords:
hypothyroidismkidney functionurinary creatinine excretion

More Related Videos

Murine Renal Transplantation Procedure18:48

Murine Renal Transplantation Procedure

Published on: July 10, 2009

29.9K
Transdermal Measurement of Glomerular Filtration Rate in Mice07:25

Transdermal Measurement of Glomerular Filtration Rate in Mice

Published on: October 21, 2018

22.0K

Related Concept Videos

Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
129
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
66
Renal Drug Clearance: Comparison Between Renal Excretion Methods01:08

Renal Drug Clearance: Comparison Between Renal Excretion Methods

Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
205
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
52
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
56
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
27