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Related Concept Videos

Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

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Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
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Psychosis and Antipsychotic Drugs: Overview01:28

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The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
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Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
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The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
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Teratogenicity01:07

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
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Long-Acting Injectable Antipsychotic Treatment during Pregnancy: A Case Series.

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International Journal of Environmental Research and Public Health
|February 25, 2023
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Summary

Long-acting injectable antipsychotics (LAIs) during pregnancy did not increase malformation risks in newborns. This study found LAI therapy safe for fetal development, with most infants born healthy and mothers maintaining stability.

Keywords:
long-acting injectable antipsychoticsneonatal outcomepregnancy

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Area of Science:

  • Obstetrics and Gynecology
  • Psychiatry
  • Pharmacology

Background:

  • Prolonged-release injectable antipsychotics (LAIs) offer consistent drug levels and improved adherence for patients with psychotic disorders.
  • Managing psychiatric conditions during pregnancy requires careful consideration of medication safety for both mother and fetus.

Purpose of the Study:

  • To investigate potential complications in newborns whose mothers received LAI therapy during pregnancy for bipolar or psychotic disorders.
  • To assess the safety of LAI treatment during gestation.

Main Methods:

  • An observational-descriptive study involving women with psychotic disorders receiving LAI therapy during pregnancy.
  • Data collected via counseling requests to a Teratology Information Center (2016-2021) and follow-up interviews.

Main Results:

  • LAI treatment during pregnancy was not linked to an increased risk of malformations in newborns.
  • The majority of infants in the study sample were born healthy.
  • Mothers on LAI therapy generally maintained psychopathological stability throughout their pregnancies.

Conclusions:

  • The use of LAIs during pregnancy appears safe, not compromising normal intrauterine development.
  • No significant major malformations were observed in the study cohort.
  • LAI therapy can be considered a viable option for managing psychiatric disorders during pregnancy.