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Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review
Joht Singh Chandan1, Kirsty R Brown1,2, Nikita Simms-Williams1
1Institute of Applied Health Research, University of Birmingham, Birmingham B15 2TT, UK.
International Journal of Environmental Research and Public Health
|February 25, 2023
Summary
Non-pharmacological treatments show promise for post-viral syndromes (PVS), including Long COVID. However, robust evidence is lacking, necessitating further clinical trials for these PVS interventions.
Area of Science:
- Medical rehabilitation
- Evidence-based medicine
- Infectious disease complications
Background:
- Post-viral syndromes (PVS), such as Long COVID, involve persistent symptoms after viral infections.
- Effective non-pharmacological treatments for PVS are not well-established.
- This review synthesizes current evidence on non-pharmacological interventions for PVS.
Approach:
- Systematic review of randomized controlled trials (RCTs) published between 2001 and 2021.
- Searched five major databases for studies on PVS interventions.
- Assessed study quality using Cochrane risk-of-bias tool and synthesized findings narratively.
Key Points:
- Five studies evaluated Pilates, music therapy, telerehabilitation, resistance exercise, and neuromodulation.
- Most interventions, except music therapy, showed some benefit for PVS symptom management.
- Evidence quality for non-pharmacological PVS treatments remains limited.
Conclusions:
- A significant gap exists in robust evidence for non-pharmacological treatments for PVS, including Long COVID.
- Urgent need for high-quality clinical trials to assess the effectiveness and cost-effectiveness of these PVS interventions.
- Further research is crucial to guide clinical practice for patients suffering from prolonged post-viral symptoms.
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