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Vitamin D Status in Patients before Thyroidectomy.

Dominika Maciejewska-Markiewicz1, Joanna Kochman1, Karolina Jakubczyk1

  • 1Department of Human Nutrition and Metabolomics, Pomeranian Medical University, 71-460 Szczecin, Poland.

International Journal of Molecular Sciences
|February 25, 2023
PubMed
Summary

Patients undergoing thyroidectomy often have severe vitamin D deficiency. Pre-operative vitamin D assessment is crucial for managing potential complications and improving patient outcomes after thyroid surgery.

Keywords:
1,25-dihydroxycholecalciferol25-hydroxycholecalciferolthyroidectomyvitamin D

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Area of Science:

  • Endocrinology
  • Nutritional Biochemistry

Background:

  • Thyroid neoplasms are common endocrine pathologies requiring surgical intervention.
  • Surgical treatment for thyroid neoplasms includes total, subtotal, or lobar excision.
  • Post-operative complications, such as hypocalcemia, can occur after thyroidectomy.

Purpose of the Study:

  • To evaluate vitamin D metabolite concentrations in patients scheduled for thyroidectomy.
  • To identify potential correlations between vitamin D status and pre-operative thyroid pathology.

Main Methods:

  • A cohort of 167 patients with thyroid pathology was studied.
  • Vitamin D metabolites, including calcidiol (25-OHD) and calcitriol (1,25-(OH)2D), and vitamin D binding protein (VDBP) were measured using ELISA.
  • Basic biochemical parameters were also assessed.

Main Results:

  • The patient cohort exhibited significant calcidiol (25-OHD) deficiency.
  • Over 80% of patients presented with extreme vitamin D deficiency (<10 ng/mL).
  • Calcitriol (1,25-(OH)2D) levels were generally adequate, despite widespread 25-OHD deficiency.

Conclusions:

  • Patients undergoing thyroidectomy frequently have marked vitamin D deficiency prior to surgery.
  • Pre-operative vitamin D status may influence post-operative recovery and prognosis.
  • Measuring vitamin D levels before thyroidectomy is recommended for clinical management and potential supplementation.