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Related Concept Videos

Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

6.8K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
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Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

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Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
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Enzymes02:34

Enzymes

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Inside living organisms, enzymes act as catalysts for many biochemical reactions involved in cellular metabolism. The role of enzymes is to reduce the activation energies of biochemical reactions by forming complexes with its substrates. The lowering of activation energies favor an increase in the rates of biochemical reactions.
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
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Drug Discovery: Overview01:26

Drug Discovery: Overview

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Principles of Drug Action01:24

Principles of Drug Action

6.2K
Drugs are chemical substances that modify biological responses by interacting with macromolecular targets such as receptors, ion channels, transporters, and enzymes. Pharmacodynamics describes the course of action of drugs leading to the physiological effect at a specific site in the body.
Drugs can be agonists or antagonists. Like the endogenous ligands, agonists always bind and activate the target to produce a cellular response. Agonist binding induces a conformational change which in turn...
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Enzyme Inhibition01:30

Enzyme Inhibition

78.9K
Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.
78.9K

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Special Issue "Targeting of Functional Proteins in Disease Therapeutics: Enzyme Function and Inhibition Studies".

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New Sight: Enzymes as Targets for Drug Development.

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Updated: Aug 9, 2025

Enzymatic Modification and Flow Cytometry Assessment of Yeast Surface Displayed Proteins
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Enzymes as Targets for Drug Development II.

Sung-Kun Kim1

  • 1Department of Natural Sciences, Northeastern State University, Broken Arrow, OK 74014, USA.

International Journal of Molecular Sciences
|February 25, 2023
PubMed
Summary

Enzymes are highly sought after drug targets in pharmaceuticals. Research focuses on developing novel therapeutic strategies by targeting enzymes for various diseases.

Area of Science:

  • Biochemistry and Medicinal Chemistry
  • Enzyme kinetics and drug discovery

Background:

  • Enzymes represent a critical class of biological molecules essential for cellular function.
  • Their crucial roles in disease pathways make them attractive targets for therapeutic intervention.

Discussion:

  • The pharmaceutical industry prioritizes enzyme targets due to their specificity and druggability.
  • Understanding enzyme mechanisms is key to designing effective and selective drugs.

Key Insights:

  • Enzymes offer precise molecular targets for drug development.
  • Targeting enzymes can lead to highly specific therapeutic effects with potentially fewer side effects.

Outlook:

  • Continued research into enzyme structure-function relationships will unlock new therapeutic avenues.

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  • Advancements in enzyme-targeted drug design promise innovative treatments for unmet medical needs.