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Antibacterial Effects of X-ray and MRI Contrast Media: An In Vitro Pilot Study

Michael P Brönnimann1, Lea Hirzberger2, Peter M Keller2

  • 1Department of Diagnostic, Interventional and Paediatric Radiology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.

International Journal of Molecular Sciences
|February 25, 2023
PubMed

Insights

Radiological contrast agents, including X-ray and MRI types, show antibacterial effects, particularly against Staphylococcus aureus and Escherichia coli. These effects are more pronounced at low concentrations and low pH levels.

Area of Science:

  • Microbiology
  • Radiology
  • Pharmacology

Background:

  • Radiological contrast agents are widely used in medical imaging.
  • Previous studies suggest potential interactions between contrast media and microorganisms.
  • The specific antibacterial effects of various contrast agents require further investigation.

Purpose of the Study:

  • To evaluate the antibacterial effects of iodinated X-ray and lanthanide MRI contrast agents.
  • To elucidate the mechanism of action of these contrast agents on bacterial growth.
  • To determine the influence of concentration and pH on the antibacterial activity.

Main Methods:

  • Testing contrast agents (Ultravist 370, Iopamiro 300, Telebrix Gastro 300, Visipaque, MultiHance, Dotarem) against six microorganisms.
  • Exposure of bacteria to contrast media at varying concentrations and pH (7.0 and 5.5).
  • Agar disk diffusion analysis and microdilution inhibition assays were employed.

Main Results:

  • Bactericidal effects were observed for microorganisms at low concentrations and low pH.
  • Significant reductions in bacterial growth were confirmed for Staphylococcus aureus and Escherichia coli.
  • Specific contrast agents demonstrated varying degrees of antibacterial activity.

Conclusions:

  • Iodinated X-ray and lanthanide MRI contrast agents possess antibacterial properties.
  • Low pH and low concentrations enhance the antimicrobial efficacy of these agents.
  • Further research is warranted to explore clinical implications and mechanisms.
Keywords:
anti-bacterial agentsanti-infective agentsantibacterial effectcontrast mediainterventionalmagnetic resonance imagingmicrobial sensitivity testsminimally invasive surgical procedures

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