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How Can Insulin Resistance Cause Alzheimer's Disease?

Ji Hye Yoon1, JooHyun Hwang1, Sung Un Son2

  • 1Age-Tech Service Convergence Major, Graduate School of East-West Medical Science, Kyung Hee University, Yongin-si 17104, Republic of Korea.

International Journal of Molecular Sciences
|February 25, 2023
PubMed

Insights

Alzheimer's disease (AD) may be caused by insulin resistance, not just amyloid beta. Understanding this link is key for early diagnosis and preventing disease progression.

Area of Science:

  • Neuroscience
  • Metabolic disorders
  • Gerontology

Background:

  • Alzheimer's disease (AD) is a leading cause of cognitive decline with no cure.
  • Current treatments focus on slowing progression via early diagnosis.
  • The amyloid cascade hypothesis is widely accepted but may not fully explain AD's cause.

Purpose of the Study:

  • To review the link between diabetes and Alzheimer's disease.
  • To explore how insulin resistance contributes to AD pathology.
  • To discuss brain metabolic and insulin insufficiency in AD development.

Main Methods:

  • Literature review of preclinical and clinical evidence.
  • Analysis of pathophysiological mechanisms.
  • Discussion of insulin resistance as a factor in AD.

Main Results:

  • Evidence suggests a connection between diabetes and AD.
  • Insulin resistance is implicated in AD development.
  • Brain metabolic and insulin insufficiency contribute to AD pathology.

Conclusions:

  • Insulin resistance is a significant factor in Alzheimer's disease development.
  • Rethinking AD's cause beyond the amyloid cascade is crucial.
  • Further research into insulin resistance may reveal new therapeutic targets.
Keywords:
amyloid betadementiahypometabolism

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