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Ferroptosis and Senescence: A Systematic Review
Donatella Coradduzza1, Antonella Congiargiu1, Zhichao Chen1
1Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
Cellular senescence and ferroptosis are key aging processes linked to age-related diseases. Understanding their connection may reveal interventions for healthy longevity.
Area of Science:
- Gerontology and cellular biology
- Molecular mechanisms of aging and cell death
Background:
- Senescence involves cellular aging, loss of function, and increased damage, contributing to age-related diseases.
- Ferroptosis is an iron-dependent cell death pathway triggered by oxidative stress, linked to disorders like neurodegeneration and cancer.
- Both processes are implicated in tissue dysfunction and inflammation during aging.
Conclusions:
- Further research is crucial to understand the complex relationship between senescence and ferroptosis in aging.
- Targeting these pathways could offer novel strategies to prevent or treat age-related conditions and promote healthy aging.
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