Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Change Point Detection in Panel Linear Regression Models Based on Jump Information Criterion.

Entropy (Basel, Switzerland)·2026
Same author

Bioinspired hierarchical fibre bundles from microfluidics for nerve regeneration.

Bioactive materials·2026
Same author

Protocol for a Prospective, Multicenter Cohort Study on the Treatment of Chronic Cardiorenal Syndrome with Qishen Yiqi Dropping Pills.

Clinical pharmacology : advances and applications·2026
Same author

Virus-encoded metabolism may support environmental stress adaptation of microbial hosts in an estuarine hypoxic zone.

Frontiers in microbiology·2026
Same author

THC and CBD Induce Heme Oxygenase-1-Dependent Cell Death and Trigger Mitochondrial Dysfunction in Human Melanoma and Cutaneous Squamous Cell Carcinoma Cells.

Antioxidants (Basel, Switzerland)·2026
Same author

Sulfate Radical-Initiated Aqueous Oxidation of Biomass Burning Tracers: A Potential Source of HULIS and aqSOA.

Environmental science & technology·2026

Related Experiment Video

Updated: Aug 9, 2025

Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration
09:23

Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration

Published on: June 16, 2015

21.0K

The Use of Collagen-Based Materials in Bone Tissue Engineering.

Lu Fan1,2, Yanru Ren3, Steffen Emmert3

  • 1NMI Natural and Medical Sciences Institute at the University of Tübingen, Markwiesenstr. 55, 72770 Reutlingen, Germany.

International Journal of Molecular Sciences
|February 25, 2023
PubMed
Summary

Synthetic bone substitute materials (BSMs) are advancing bone tissue engineering (BTE). Collagen-based materials show promise for bone regeneration, but require improvements in mechanical properties and osteoconductivity for clinical use.

Keywords:
bone substitute materialsbone tissue engineeringcollagencollagen modificationscomposite bone scaffolds

More Related Videos

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering
09:49

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

Published on: February 23, 2024

1.8K
Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

9.8K

Related Experiment Videos

Last Updated: Aug 9, 2025

Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration
09:23

Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration

Published on: June 16, 2015

21.0K
Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering
09:49

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

Published on: February 23, 2024

1.8K
Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

9.8K

Area of Science:

  • Biomaterials Science
  • Orthopedic Research
  • Tissue Engineering

Background:

  • Synthetic bone substitute materials (BSMs) are increasingly replacing autologous grafting in bone tissue engineering (BTE).
  • Collagen type I, a primary bone matrix component, is crucial for developing ideal synthetic BSMs.
  • Despite advancements in collagen research and material preparation, challenges like poor mechanical properties and fast degradation hinder clinical translation.

Purpose of the Study:

  • To review the latest applications of collagen-based materials in bone regeneration.
  • To highlight the potential of collagen-based biomimetic BSMs in BTE.
  • To identify future development directions for collagen-based materials in BTE over the next decade.

Main Methods:

  • Literature review of approved collagen-based bone substitute materials on the market.
  • Analysis of current research trends in collagen-based biomimetic BSMs.
  • Synthesis of information on collagen types, preparation techniques, and modification technologies.

Main Results:

  • Collagen-based materials are central to developing synthetic BSMs for BTE.
  • Current collagen-based materials face limitations in mechanical strength, degradation rate, and osteoconductive activity.
  • Combinations with inorganic materials and bioactive substances are explored to enhance BSM performance.

Conclusions:

  • Collagen-based materials are vital for bone regeneration, but require further optimization for clinical application.
  • Future research should focus on overcoming current limitations to improve the efficacy of collagen-based BSMs in BTE.
  • The review provides insights into the evolving landscape and future potential of collagen in bone tissue engineering.