Adipose-Derived Mesenchymal Stromal Cells in Basic Research and Clinical Applications
Katarzyna Czerwiec1, Małgorzata Zawrzykraj1, Milena Deptuła2
1Division of Clinical Anatomy, Department of Anatomy, Faculty of Medicine, Medical University of Gdansk, 80-211 Gdańsk, Poland.
International Journal of Molecular Sciences
|February 25, 2023
Summary
Adipose-derived mesenchymal stromal cells (AD-MSCs) are promising for regenerative medicine due to their accessibility and therapeutic potential in various diseases. Ongoing research and clinical trials highlight their effectiveness and future applications in advanced stem cell therapies.
Area of Science:
- Regenerative Medicine
- Cell Therapy
- Immunomodulation
Background:
- Adipose-derived mesenchymal stromal cells (AD-MSCs) are readily sourced from adipose tissue.
- AD-MSCs exhibit significant regenerative potential and immunomodulatory properties.
- These cells are attractive for therapeutic applications due to ease of access and abundance.
Purpose of the Study:
- To review current knowledge and applications of AD-MSCs.
- To highlight AD-MSC potential in wound healing, orthopedic, cardiovascular, and autoimmune diseases.
- To discuss the future of AD-MSCs, including genetic modification for next-generation therapies.
Main Methods:
- Review of existing literature and clinical trial data on AD-MSCs.
- Presentation of AD-MSC applications in pre-clinical models.
- Analysis of AD-MSC effectiveness in clinical studies.
Main Results:
- AD-MSCs show proven effectiveness in numerous clinical trials.
- Successful applications demonstrated in pre-clinical and clinical settings.
- AD-MSCs are viable candidates for advanced, modified stem cell therapies.
Conclusions:
- AD-MSCs hold significant promise for various therapeutic areas.
- Their regenerative and immunomodulatory functions are key to their potential.
- Further exploration is warranted for optimizing AD-MSC applications and modifications.
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