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Peptide Designs for Use in Caries Management: A Systematic Review
Olivia Lili Zhang1, John Yun Niu1, Ollie Yiru Yu1
1Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.
International Journal of Molecular Sciences
|February 25, 2023
Summary
This review highlights template-based and conjugation methods as leading peptide design strategies for caries management. These approaches are crucial for developing novel antimicrobial and mineralizing peptides to combat tooth decay.
Area of Science:
- Biomaterials Science
- Dental Research
- Peptide Design
Background:
- Dental caries remains a significant global health issue.
- Peptides offer promising therapeutic potential for caries management due to their antimicrobial and remineralization properties.
- Systematic reviews are essential to consolidate knowledge on peptide design strategies for dental applications.
Approach:
- A systematic review of in vitro studies was conducted to identify and analyze peptide design methods for caries management.
- Two independent researchers screened 3592 publications, selecting 62 relevant studies.
- Risk of bias assessment was performed on the included studies.
Key Points:
- Template-based design (66%) and conjugation methods (19%) were the most prevalent strategies for designing antimicrobial peptides.
- Template-based design (70%) and de novo design (20%) were common for mineralizing peptides.
- A significant portion of studies (71%) presented a medium risk of bias.
Conclusions:
- Template-based and conjugation methods are the primary approaches for developing peptides in caries management.
- Further research with robust methodologies is needed to mitigate bias and optimize peptide efficacy.
- Peptide-based therapies hold significant promise for future caries prevention and treatment.
