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Osteoclasts in Bone Remodeling

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Hormones and Bone Tissue

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Role of Vitamins in Maintaining Bone Health

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
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Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...

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Related Experiment Video

Updated: Aug 9, 2025

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Published on: July 21, 2023

Antisclerostin Effect on Osseointegration and Bone Remodeling.

Bárbara Alexandra do Amaral Couto¹, Juliana Campos Hasse Fernandes², Mariana Saavedra-Silva³

¹Faculty of Dental Medicine, Universidade Católica Portuguesa, 3505-606 Viseu, Portugal.

Journal of Clinical Medicine

|February 25, 2023

Summary

Antisclerostin administration shows promise in enhancing bone formation and osseointegration for dental implants. Further research is needed to confirm these effects due to study limitations and heterogeneity.

Keywords:

antisclerostin bone formation bone remodeling osseointegration sclerostin antibody

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Area of Science:

Orthopedics and Dental Implantology
Bone Biology and Therapeutics

Background:

Antisclerostin (Scl-Ab) is a therapeutic target for bone anabolism.
Understanding its role in osseointegration and bone remodeling is crucial for implantology.

Purpose of the Study:

To review existing literature on local or systemic antisclerostin administration.
To evaluate its effects on osseointegration of dental/orthopedic implants and bone remodeling.

Main Methods:

Extensive literature search across major databases (MEDLINE/PubMed, Web of Science).
Inclusion of case reports, clinical trials, and animal studies.
Analysis of 19 selected articles (16 animal, 3 human RCTs).

Main Results:

Studies indicated increased bone-implant contact and bone mineral density with antisclerostin treatment.
Evidence suggests stimulation of bone formation and remodeling, with identified biomarkers.
Limitations include a low number of human studies and heterogeneity in study designs and parameters.

Conclusions:

Antisclerostin administration shows potential for accelerating bone remodeling and osseointegration.
Further high-quality human studies are necessary to validate these findings and optimize therapeutic use.