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Immunotherapy for Prostate Cancer: A Current Systematic Review and Patient Centric Perspectives

Laeeq Ur Rehman1, Muhammad Hassan Nisar2, Wajeeha Fatima3

  • 1Department of Research, Continental Medical College, Lahore 54000, Pakistan.

Journal of Clinical Medicine
|February 25, 2023
PubMed

Insights

Immunotherapy shows promise for prostate cancer care, with ipilimumab demonstrating improved survival trends. Ongoing trials are exploring immune checkpoint inhibitors and adjuvant therapies to enhance patient outcomes.

Area of Science:

  • Oncology
  • Immunology

Background:

  • Prostate cancer is a leading cause of cancer diagnosis and mortality globally.
  • There is a critical need for improved treatment strategies to optimize prostate cancer care.

Purpose of the Study:

  • To systematically review Phase III clinical trials of immunotherapy for prostate cancer.
  • To create an index of ongoing Phase I-III clinical trials in prostate cancer immunotherapy.

Main Methods:

  • Systematic review of completed Phase III clinical trials involving immunotherapy agents (DCVAC, ipilimumab, personalized peptide vaccine, PROSTVAC).
  • Compilation of a 2022 clinical trial index of ongoing Phase I-III trials.

Main Results:

  • Four Phase III trials with 3588 participants were analyzed.
  • Ipilimumab showed promising results with improved overall survival trends.
  • 68 ongoing trials involving 7923 participants are registered, with expected completion dates up to June 2028.

Conclusions:

  • Immunotherapy, including immune checkpoint inhibitors and adjuvant therapies, is an emerging and significant treatment option for prostate cancer.
  • Ongoing clinical trials are crucial for advancing the understanding and application of immunotherapy in prostate cancer management.
Keywords:
clinical trialsimmunotherapymen’s healthprostate cancertherapeutic developments

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