Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

265
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
265
Operant Conditioning Intervention01:24

Operant Conditioning Intervention

97
Operant conditioning serves as a foundational principle in therapeutic interventions aimed at modifying maladaptive behaviors. Central to this approach is the notion that behaviors, both adaptive and maladaptive, are learned through reinforcement. By analyzing the environmental factors that reinforce problematic behaviors, clinicians can design interventions to weaken these reinforcements and replace maladaptive behaviors with healthier alternatives.
In operant conditioning, behaviors that are...
97
Pneumonia IV: Management01:28

Pneumonia IV: Management

411
The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
411
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

180
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
180
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

338
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
338
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

128
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
128

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-time prediction of atrial fibrillation in intensive care unit: a meta-learning approach.

JAMIA open·2026
Same author

Behaviour artificial intelligence technology to support the decision-making process of continuation or withdrawal of life-sustaining therapy.

Intensive care medicine experimental·2026
Same author

Towards Fingerprint Mosaicking Artifact Detection: A Self-Supervised Deep Learning Approach.

Sensors (Basel, Switzerland)·2026
Same author

Prophylactic Enoxaparin Reduces Symptomatic Venous Thromboembolism Compared With No Chemoprophylaxis Within 95 Days After Knee Arthroscopy.

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association·2026
Same author

Consensus statement from the 2025 Delphi panel on cerebral microdialysis in critical care.

Critical care (London, England)·2026
Same author

Shortening Time to Arrival in Out-of-Hospital Cardiac Arrest by Implementing a Dual Dispatch Strategy of EMS and Volunteer Fire Service-A Simulation Study.

Journal of clinical medicine·2026

Related Experiment Video

Updated: Aug 9, 2025

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

2.1K

Development of a Reinforcement Learning Algorithm to Optimize Corticosteroid Therapy in Critically Ill Patients with

Razvan Bologheanu1,2, Lorenz Kapral2, Daniel Laxar2

  • 1Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, 1090 Vienna, Austria.

Journal of Clinical Medicine
|February 25, 2023
PubMed
Summary

Reinforcement learning suggests a more restrictive corticosteroid policy in sepsis patients, potentially reducing intensive care unit mortality. This precision-medicine approach optimizes steroid use based on clinical data.

Keywords:
artificial intelligencecorticosteroidsoutcomesreinforcement learningsepsis

More Related Videos

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
14:54

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

11.2K
A Data-Driven Approach to Quantifying Immune States in Sepsis
07:42

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

287

Related Experiment Videos

Last Updated: Aug 9, 2025

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

2.1K
A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
14:54

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

11.2K
A Data-Driven Approach to Quantifying Immune States in Sepsis
07:42

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

287

Area of Science:

  • Critical Care Medicine
  • Artificial Intelligence in Healthcare
  • Pharmacology

Background:

  • Optimal corticosteroid use in sepsis remains controversial.
  • Current clinical practice varies widely.
  • Data from 3051 ICU admissions were analyzed.

Purpose of the Study:

  • To derive an optimal corticosteroid treatment policy for sepsis using reinforcement learning.
  • To compare the derived policy with actual clinical practice.

Main Methods:

  • An actor-critic reinforcement learning (RL) algorithm was developed.
  • The algorithm used ICU mortality as a reward signal.
  • Trained on 277 clinical parameters from time-series data.

Main Results:

  • RL agent policy agreed with clinicians 59% of the time.
  • RL agent suggested withholding corticosteroids more often (62% vs 52%).
  • RL agent's policy showed a higher expected reward and lower ICU mortality.

Conclusions:

  • Individualized corticosteroid therapy in sepsis may improve mortality.
  • Optimal policy appears more restrictive than current practice.
  • Study supports a precision-medicine approach for future trials.