Design and Protocol for Beijing Hospital Takayasu Arteritis (BeTA) Biobank.

Area of Science:

• Vascular Surgery
• Immunology
• Genomics

Background:

• Limited understanding of Takayasu arteritis (TAK) pathogenesis, surgical indications, and disease markers.
• Need for comprehensive data collection to support translational research in TAK.
• Existing research is hindered by fragmented clinical and biological data.

Purpose of the Study:

• Introduce the design and protocol of the Beijing Hospital Takayasu Arteritis (BeTA) Biobank.
• Establish a centralized repository for clinical, imaging, and biological samples from TAK patients.
• Facilitate future multiomic studies and biomarker discovery for TAK.

Main Methods:

• Biobank established within Beijing Hospital's Vascular Surgery department and Clinical Biological Sample Management Center.
• Collection of comprehensive clinical data: demographics, labs, imaging, surgical details, complications, and follow-up.
• Storage of biological samples: blood (plasma, serum, cells) and vascular/adipose tissues.

Main Results:

• The BeTA Biobank successfully collected and stored diverse clinical and biological data from TAK patients.
• The biobank provides a foundation for creating a multiomic database for Takayasu arteritis.
• The collected data and samples are poised to aid in identifying disease markers and potential drug targets.

Conclusions:

• The BeTA Biobank protocol is established for systematic data and sample collection in Takayasu arteritis.
• This biobank will be instrumental in advancing the understanding and treatment of TAK.
• Future research utilizing the BeTA Biobank is expected to yield significant insights into TAK pathogenesis and management.