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The Role of Tight Junctions in Atopic Dermatitis: A Systematic Review

Spyridoula Katsarou1, Michael Makris2, Efstratios Vakirlis3

  • 11st Department of Dermatology and Venereology, Medical School, National and Kapodistrian University of Athens, Andreas Syggros Hospital, 11528 Athens, Greece.

Journal of Clinical Medicine
|February 25, 2023
PubMed
Abstract

Keywords:
atopic dermatitisatopic eczemaclaudinstight junctions

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Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
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Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
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