Endoscopic Grading as a Predictor to Develop Strictures in Corrosive Esophagitis in Children

Area of Science:

• Pediatric Gastroenterology
• Toxicology
• Endoscopic Medicine

Background:

• Corrosive esophagitis incidence is rising in developing nations.
• Acids and alkalis are key factors in pediatric corrosive esophagitis.
• This study investigates incidence and endoscopic grading in a pediatric cohort.

Purpose of the Study:

• To determine the incidence of corrosive esophagitis in children.
• To establish the correlation between endoscopic grading and late complications.
• To identify risk factors for stricture formation.

Main Methods:

• Retrospective analysis of pediatric patients with corrosive ingestion.
• Data collected over a 10-year period from a single center.
• Endoscopic grading used to assess injury severity.

Main Results:

• 22 pediatric patients analyzed; 59.09% were girls.
• Laboratory tests showed poor correlation with injury severity.
• Grades 2B and 3A esophagitis were associated with strictures (60.60% of cases).
• Pro-inflammatory cytokines (IL-2, IL-5, Interferon-gamma) were elevated.
• Malnutrition and prolonged hospitalization were common in severe cases (Grade 3A).

Conclusions:

• Corrosive esophagitis incidence is low in the studied region.
• Endoscopic grading effectively predicts the likelihood of strictures.
• Grades 2B and 3A esophagitis necessitate close monitoring for stricture development.
• Preventing strictures and malnutrition is critical for patient outcomes.