Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fungal Phylum Ascomycota01:28

Fungal Phylum Ascomycota

87
Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
87
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

297
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
297
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

292
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
292
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

391
The pathophysiology of pneumonia involves the following steps:
391
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

186
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
186
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

885
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
885

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Arsenic Trioxide and All-Trans Retinoic Acid Combination Therapy for the Treatment of High-Risk Acute Promyelocytic Leukemia: Results From the APOLLO Trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2025
Same author

Epidemiology and Prognostic Factors Associated With Mold-Positive Blood Cultures: 10-Year Data From a French Prospective Surveillance Program (2012-2022).

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025
Same author

Correction: Need for ICU and outcome of critically ill patients with COVID-19 and haematological malignancies: results from the EPICOVIDEHA survey.

Infection·2024
Same author

<i>Fusarium</i>, <i>Scedosporium</i> and Other Rare Mold Invasive Infections: Over Twenty-Five-Year Experience of a European Tertiary-Care Center.

Journal of fungi (Basel, Switzerland)·2024
Same author

Need for ICU and outcome of critically ill patients with COVID-19 and haematological malignancies: results from the EPICOVIDEHA survey.

Infection·2024
Same author

COVID-19 and hairy-cell leukemia: an EPICOVIDEHA survey.

Blood advances·2022

Related Experiment Video

Updated: Aug 9, 2025

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
08:01

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology

Published on: March 22, 2012

28.1K

Invasive Pulmonary Aspergillosis.

Marie-Pierre Ledoux1, Raoul Herbrecht1

  • 1Department of Hematology, Institut de Cancérologie de Strasbourg Europe (ICANS), 67033 Strasbourg, France.

Journal of Fungi (Basel, Switzerland)
|February 25, 2023
PubMed
Summary
This summary is machine-generated.

Invasive pulmonary aspergillosis is increasingly diagnosed in diverse patient groups beyond neutropenia. Early detection via imaging and biomarkers, alongside new antifungals, improves survival for this serious fungal infection.

Keywords:
galactomannanhematopoietic stem cell transplantationisavuconazoleleukemialiposomal amphotericin Bneutropeniaposaconazolereviewsolid organ transplantationvoriconazole

More Related Videos

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
09:52

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Published on: March 9, 2018

10.6K
Confocal Laser Scanning Microscopy-Based Quantitative Analysis of Aspergillus fumigatus Conidia Distribution in Whole-Mount Optically Cleared Mouse Lung
15:01

Confocal Laser Scanning Microscopy-Based Quantitative Analysis of Aspergillus fumigatus Conidia Distribution in Whole-Mount Optically Cleared Mouse Lung

Published on: September 18, 2021

3.4K

Related Experiment Videos

Last Updated: Aug 9, 2025

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
08:01

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology

Published on: March 22, 2012

28.1K
Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
09:52

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Published on: March 9, 2018

10.6K
Confocal Laser Scanning Microscopy-Based Quantitative Analysis of Aspergillus fumigatus Conidia Distribution in Whole-Mount Optically Cleared Mouse Lung
15:01

Confocal Laser Scanning Microscopy-Based Quantitative Analysis of Aspergillus fumigatus Conidia Distribution in Whole-Mount Optically Cleared Mouse Lung

Published on: September 18, 2021

3.4K

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Pulmonology

Background:

  • Invasive pulmonary aspergillosis (IPA) incidence is rising.
  • Risk factors are expanding beyond neutropenia to include new anticancer drugs, viral pneumonias, and hepatic dysfunction.
  • Classical clinical signs are often unspecific in at-risk populations.

Purpose of the Study:

  • To review the evolving landscape of IPA diagnosis and management.
  • To highlight advances in diagnostic work-up and therapeutic strategies.
  • To emphasize the importance of recognizing new risk factors and diagnostic tools.

Main Methods:

  • Review of current literature and diagnostic guidelines for IPA.
  • Analysis of imaging techniques (CT, PET) in diagnosing pulmonary lesions.
  • Evaluation of mycological diagnostic arguments, including biomarkers (galactomannan, DNA) and direct methods.
  • Discussion of therapeutic advancements and future antifungal development.

Main Results:

  • Computed tomography (CT) is crucial for assessing pulmonary lesions, requiring acknowledgment of varied features.
  • Positron-emission tomography (PET) offers supplementary diagnostic and follow-up information.
  • Diagnosis of probable IPA relies on risk factors, suggestive radiology, and detection of biomarkers (galactomannan, DNA) or direct evidence in blood and bronchoalveolar lavage fluid.
  • Mycological confirmation can be challenging due to difficulties in obtaining sterile site biopsies.

Conclusions:

  • IPA diagnosis requires a comprehensive approach integrating clinical, radiological, and microbiological data, especially in non-neutropenic patients.
  • Improved diagnostic strategies and newer antifungal agents have enhanced patient survival.
  • Ongoing research into novel antifungals is critical for managing this opportunistic infection.