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Inborn Errors of Immunity Causing Pediatric Susceptibility to Fungal Diseases
Peter Olbrich1,2,3, Donald C Vinh4,5,6
1Pediatric Infectious Diseases, Rheumatology and Immunology Unit, Hospital Universitario, Virgen del Rocío, 41013 Sevilla, Spain.
Abstract:
Inborn errors of immunity are a heterogeneous group of genetically determined disorders that compromise the immune system, predisposing patients to infections, autoinflammatory/autoimmunity syndromes, atopy/allergies, lymphoproliferative disorders, and/or malignancies. An emerging manifestation is susceptibility to fungal disease, caused by yeasts or moulds, in a superficial or invasive fashion. In this review, we describe recent advances in the field of inborn errors of immunity associated with increased susceptibility to fungal disease.
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