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A Prospective Study of Longitudinal Risks of Cognitive Deficit for People Undergoing Glioblastoma Surgery Using a
Rohitashwa Sinha1,2,3, Riccardo Masina1, Cristina Morales1
1Department of Neurosurgery, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.
Journal of Personalized Medicine
|February 25, 2023
Summary
Surgery for glioblastoma significantly increases risks to cognitive function, particularly attention, memory, and perception. However, a natural recovery period is observed 4-6 weeks post-surgery before radiotherapy begins.
Area of Science:
- Neuroscience
- Oncology
- Cognitive Psychology
Background:
- Glioblastoma surgery poses significant risks to patient cognitive function.
- Limited data exist on perioperative cognitive risks, especially before radiotherapy.
- Cognitive deficits may worsen post-surgery in glioblastoma patients undergoing maximal treatment.
Purpose of the Study:
- To prospectively assess perioperative cognitive function in glioblastoma patients.
- To investigate changes in cognitive deficit risk before and after glioblastoma surgery.
- To identify a potential recovery window for cognitive function post-surgery.
Main Methods:
- Prospective, longitudinal, observational study of 49 glioblastoma participants.
- Utilized longitudinal electronic cognitive testing at multiple perioperative time points (A1, A2, A3).
- Compared participant cognitive risk to normative data, analyzing risks across cognitive domains.
Main Results:
- Pre-surgery (A1), 5/6 cognitive domains showed increased deficit risk, notably Attention (OR=31.19), Memory (OR=97.38), and Perception (OR=213.75).
- Cognitive risks markedly increased in the early post-surgery period (A2).
- A trend towards risk reduction was observed 4-6 weeks post-surgery (A3), before radiotherapy, independent of covariates.
Conclusions:
- Glioblastoma surgery temporarily exacerbates cognitive deficits, with a notable recovery trend within 4-6 weeks post-operation.
- Personalized cognitive deficit profiles can be established during this recovery window.
- Future research should explore personalized rehabilitation strategies during this early postoperative period.
