Yeast Hydrolysate and Postmenopausal Osteoporosis
Yang Hee Hong1, Eun Young Jung2
1Department of Beauty and Art, Suwon Women's University, Suwon 441-748, Republic of Korea.
Journal of Personalized Medicine
|February 25, 2023
Summary
Yeast hydrolysate (YH) may help treat bone loss in osteoporosis by normalizing testosterone levels. This study found YH improved bone markers and microarchitecture in an ovariectomized rat model.
Area of Science:
- Biochemistry
- Endocrinology
- Bone Biology
Background:
- Postmenopausal osteoporosis is characterized by significant bone loss.
- Ovariectomy (OVX) in rats is a common model for studying postmenopausal osteoporosis.
- Estrogen deficiency leads to decreased bone mineral density and increased fracture risk.
Purpose of the Study:
- To investigate the therapeutic potential of yeast hydrolysate (YH) in mitigating bone loss associated with postmenopausal osteoporosis.
- To evaluate the effects of YH on bone turnover markers and bone microarchitecture in an OVX rat model.
Main Methods:
- An ovariectomy (OVX) rat model was established to induce osteoporosis.
- Rats were divided into five groups: sham, OVX control, estrogen treatment, YH 0.5% supplementation, and YH 1% supplementation.
- Serum testosterone, calcium, alkaline phosphatase, osteocalcin, and cross-linked telopeptides of type I collagen were measured.
- Trabecular bone microarchitecture was analyzed.
Main Results:
- Yeast hydrolysate (YH) treatment normalized serum testosterone concentrations in OVX rats.
- YH supplementation significantly increased serum calcium levels.
- YH reduced levels of bone resorption markers (alkaline phosphatase, osteocalcin, and cross-linked telopeptides of type I collagen).
- YH treatment showed a positive trend in improving trabecular bone microarchitecture.
Conclusions:
- Yeast hydrolysate (YH) demonstrates potential therapeutic effects against bone loss in postmenopausal osteoporosis.
- The bone-protective effects of YH may be attributed to the normalization of serum testosterone levels.
- YH influences key bone turnover markers and shows promise for improving bone health.
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