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The Role of V-Set Ig Domain-Containing 4 in Chronic Kidney Disease Models

Sang Youb Han1, Jung Yeon Ghee2, Jin Joo Cha2

  • 1Department of Internal Medicine, Inje University, Ilsan-Paik Hospital, Goyang 10380, Republic of Korea.

Life (Basel, Switzerland)
|February 25, 2023
PubMed

Insights

V-set Ig domain-containing 4 (VSIG4) protein and mRNA expression increased in mouse models of kidney injury. This suggests VSIG4 may play a role in the progression of chronic kidney disease.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Immunology

Background:

  • V-set Ig domain-containing 4 (VSIG4) is known to regulate inflammatory responses and is implicated in various diseases.
  • The specific role of VSIG4 in the context of kidney diseases remains largely unexplored.

Purpose of the Study:

  • To investigate the expression and potential role of VSIG4 in different models of kidney injury.
  • To determine if VSIG4 is upregulated in response to kidney damage and if it correlates with disease markers.

Main Methods:

  • Utilized unilateral ureteral obstruction (UUO) and doxorubicin-induced kidney injury mouse models.
  • Examined VSIG4 mRNA and protein expression in kidney tissues and urinary samples.
  • Assessed VSIG4 levels in cultured podocytes subjected to doxorubicin treatment.
  • Correlated urinary VSIG4 levels with urinary albumin levels.

Main Results:

  • Urinary VSIG4 protein levels were significantly elevated in UUO mice compared to controls.
  • Both mRNA and protein expression of VSIG4 were upregulated in the kidneys of UUO mice.
  • In doxorubicin-induced kidney injury, urinary VSIG4 and albumin levels were significantly increased.
  • A strong positive correlation was found between urinary VSIG4 and albumin levels (r = 0.912, p < 0.001).
  • Intrarenal VSIG4 expression and podocyte VSIG4 expression were upregulated following doxorubicin treatment.

Conclusions:

  • VSIG4 expression is upregulated in both UUO and doxorubicin-induced kidney injury models.
  • These findings suggest that VSIG4 may be involved in the pathogenesis and progression of chronic kidney disease.
Keywords:
UUOVSIG4doxorubicinkidneypodocyte

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