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Updated: Aug 9, 2025

Refined Murine Model of Idiopathic Pulmonary Fibrosis
Published on: June 17, 2025
Trials and Treatments: An Update on Pharmacotherapy for Idiopathic Pulmonary Fibrosis
Lorraine Thong1, Enda James McElduff2, Michael Thomas Henry3
1Department of Clinical Medicine, Trinity College Dublin, D08 W9RT Dublin, Ireland.
Abstract:
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive fibrosing interstitial lung disease that occurs predominantly in the older population. There is increasing incidence and prevalence in IPF globally. The emergence of anti-fibrotic therapies in the last decade have improved patient survival though a cure is yet to be developed. In this review article, we aim to summarize the existing and novel pharmacotherapies for the treatment of IPF (excluding treatments for acute exacerbations), focusing on the current knowledge on the pathophysiology of the disease, mechanism of action of the drugs, and clinical trials.
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