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Updated: Aug 8, 2025
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Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
Published on: February 23, 2020
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Dynamic Loading-A New Marker for Abdominal Aneurysm Growth?
John Friesen1, Lucas Stein1, Farzin Adili2
1Chair of Fluid Systems, Technical University Darmstadt, 64287 Darmstadt, Germany.
Medicina (Kaunas, Lithuania)
|February 25, 2023
Summary
Continuous monitoring of blood pressure and heart rate via mobile devices can enhance abdominal aortic aneurysm (AAA) risk assessment. Load functions using these vitals may predict AAA growth, enabling personalized patient care.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Medical Device Technology
Background:
- Non-invasive mobile health technologies enable continuous vital sign monitoring.
- Continuous tracking of blood pressure and heart rate is crucial for assessing patient health status.
- Abdominal aortic aneurysm (AAA) risk assessment can benefit from personalized, data-driven approaches.
Purpose of the Study:
- To investigate the potential of continuous blood pressure and heart rate monitoring for abdominal aortic aneurysm (AAA) risk assessment.
- To introduce a novel load function and energy function approach for quantifying dynamic load on AAAs.
- To hypothesize and outline a study for validating the correlation between load functions and AAA growth.
Main Methods:
- Utilizing continuous blood pressure, heart rate, and aneurysm stiffness as input parameters.
- Developing and applying load and energy functions to quantify dynamic forces on abdominal aortic aneurysms (AAAs).
- Proposing a study design for hypothesis testing and performing uncertainty quantification on input and derived metrics.
Main Results:
- The study proposes a method to quantify dynamic load on abdominal aortic aneurysms (AAAs) using continuous physiological data.
- A hypothesis is formulated suggesting a correlation between these load functions and AAA growth.
- A framework for uncertainty quantification is presented for the developed metrics.
Conclusions:
- Continuous monitoring via mobile devices offers a promising avenue for personalized abdominal aortic aneurysm (AAA) risk assessment.
- The proposed load and energy functions provide a novel method for quantifying biomechanical stress on AAAs.
- Further studies are needed to validate the predictive capabilities of these functions for AAA growth.
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