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Related Concept Videos

Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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Aneurysm I: Introduction01:30

Aneurysm I: Introduction

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An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
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Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

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Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
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Abdominal Aorta01:25

Abdominal Aorta

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Once the aorta traverses the diaphragmatic plane at the aortic hiatus, it is known as the abdominal aorta. This anatomical structure is positioned leftward of the spinal column, encased within a cocoon of adipose tissue behind the peritoneal cavity. It terminates at the L4 vertebra, where it splits into the common iliac arteries. Prior to this bifurcation, the abdominal aorta gives rise to several vital branches.
The celiac trunk, a singular artery, divides into the left gastric artery, which...
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Impact Loading01:19

Impact Loading

246
Impact loading occurs when a moving object collides with a stationary structure, such as a rod with a uniform cross-sectional area fixed at one end. Under these conditions, the rod absorbs the kinetic energy from the striking object, leading to deformation and subsequent stress development. As the rod returns to its original position and reaches maximum stress, the absorbed energy, initially manifested as kinetic energy, transforms entirely into strain energy.
In cases of elastic deformation,...
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Deformation of Member under Multiple Loadings01:11

Deformation of Member under Multiple Loadings

200
When a rod is made of different materials or has various cross-sections, it must be divided into parts that meet the necessary conditions for determining the deformation. These parts are each characterized by their internal force, cross-sectional area, length, and modulus of elasticity. These parameters are then used to compute the deformation of the entire rod.
In the case of a member with a variable cross-section, the strain is not constant but depends on the position. The deformation of an...
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Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
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Dynamic Loading-A New Marker for Abdominal Aneurysm Growth?

John Friesen1, Lucas Stein1, Farzin Adili2

  • 1Chair of Fluid Systems, Technical University Darmstadt, 64287 Darmstadt, Germany.

Medicina (Kaunas, Lithuania)
|February 25, 2023
PubMed
Summary

Continuous monitoring of blood pressure and heart rate via mobile devices can enhance abdominal aortic aneurysm (AAA) risk assessment. Load functions using these vitals may predict AAA growth, enabling personalized patient care.

Keywords:
aneurysmaneurysm modelingpulse tracking

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Medical Device Technology

Background:

  • Non-invasive mobile health technologies enable continuous vital sign monitoring.
  • Continuous tracking of blood pressure and heart rate is crucial for assessing patient health status.
  • Abdominal aortic aneurysm (AAA) risk assessment can benefit from personalized, data-driven approaches.

Purpose of the Study:

  • To investigate the potential of continuous blood pressure and heart rate monitoring for abdominal aortic aneurysm (AAA) risk assessment.
  • To introduce a novel load function and energy function approach for quantifying dynamic load on AAAs.
  • To hypothesize and outline a study for validating the correlation between load functions and AAA growth.

Main Methods:

  • Utilizing continuous blood pressure, heart rate, and aneurysm stiffness as input parameters.
  • Developing and applying load and energy functions to quantify dynamic forces on abdominal aortic aneurysms (AAAs).
  • Proposing a study design for hypothesis testing and performing uncertainty quantification on input and derived metrics.

Main Results:

  • The study proposes a method to quantify dynamic load on abdominal aortic aneurysms (AAAs) using continuous physiological data.
  • A hypothesis is formulated suggesting a correlation between these load functions and AAA growth.
  • A framework for uncertainty quantification is presented for the developed metrics.

Conclusions:

  • Continuous monitoring via mobile devices offers a promising avenue for personalized abdominal aortic aneurysm (AAA) risk assessment.
  • The proposed load and energy functions provide a novel method for quantifying biomechanical stress on AAAs.
  • Further studies are needed to validate the predictive capabilities of these functions for AAA growth.