Biosynthetic Gene Clusters from Swine Gut Microbiome
Leli Wang1,2,3, Yiru Zhang1, Juan Xu1
1Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Microorganisms
|February 25, 2023
Summary
Antibiotic resistance is a major veterinary challenge. This study explores natural products from biosynthetic gene clusters (BGCs) in pig intestines as potential alternatives, finding unique BGCs in different gut regions.
Area of Science:
- Microbiology
- Veterinary Science
- Biotechnology
Background:
- Antibiotic abuse in veterinary medicine drives resistance gene spread.
- Cost-effective antibiotic alternatives are needed in pig production.
- Natural products from biosynthetic gene clusters (BGCs) show therapeutic promise.
Purpose of the Study:
- To investigate the diversity and composition of BGCs in porcine intestinal microbiomes.
- To compare BGCs between the ileum and colon of pigs.
- To identify potential natural products for swine health.
Main Methods:
- Sequence alignment against the antiSMASH database.
- Analysis of microbial BGCs in porcine ileum and colon samples.
Main Results:
- Diverse secondary metabolite genes were detected in porcine intestines.
- Resorcinol BGCs were more abundant in the ileum.
- Arylpolyene BGCs were enriched in the colon.
Conclusions:
- Significant differences in BGC composition exist between pig ileum and colon.
- These findings offer insights for utilizing BGCs in livestock.
- Further attention to BGCs in gut microbiota is crucial for healthy swine production.
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