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Anticancer Mechanism of Flavonoids on High-Grade Adult-Type Diffuse Gliomas

Shu Chyi Wong1, Muhamad Noor Alfarizal Kamarudin1, Rakesh Naidu1

  • 1Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor Darul Ehsan, Malaysia.

Nutrients
|February 25, 2023
PubMed

Insights

Dietary flavonoids show promise in targeting multiple molecular pathways to combat high-grade diffuse gliomas. Further clinical studies are needed to confirm their efficacy and safety for patients.

Area of Science:

  • Oncology
  • Neuroscience
  • Pharmacology

Background:

  • High-grade adult-type diffuse gliomas are aggressive central nervous system tumors with poor survival rates.
  • Intra-tumor heterogeneity presents a significant challenge in effective glioma treatment.
  • Dietary flavonoids offer a potential strategy to target multiple molecular pathways in gliomas.

Purpose of the Study:

  • To review the anticancer mechanisms of various dietary flavonoids against high-grade adult-type diffuse gliomas.
  • To identify common molecular targets of flavonoids relevant to glioma progression.
  • To discuss the clinical relevance of these targets and compare flavonoids with existing small molecule inhibitors.

Main Methods:

  • Literature review of preclinical studies on dietary flavonoids and high-grade adult-type diffuse gliomas.
  • Analysis of flavonoid mechanisms targeting cell proliferation, apoptosis, oxidative stress, cell cycle, migration, invasion, autophagy, and DNA repair.
  • Comparison of flavonoid targets with those of small molecule inhibitors used in glioma treatment.

Main Results:

  • Flavonoids like quercetin, rutin, and EGCG exhibit anticancer effects by modulating key molecules (e.g., Bax, Bcl-2, caspases, p53, MMPs).
  • These flavonoids target critical cellular processes including apoptosis, cell cycle progression, and invasion pathways.
  • Flavonoid targets show clinical relevance and can be compared to pathways affected by small molecule inhibitors.

Conclusions:

  • Dietary flavonoids possess multifaceted anticancer properties against high-grade adult-type diffuse gliomas.
  • Flavonoids represent a promising avenue for novel therapeutic strategies due to their ability to target tumor heterogeneity.
  • Further clinical investigation is essential to validate the therapeutic potential and safety of flavonoids in glioma patients.
Keywords:
anticancerflavonoidshigh-grade adult-type diffuse gliomas

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