The (Poly)phenol-Carbohydrate Combination for Diabetes: Where Do We Stand?
Ana Marta de Matos1, Regina Menezes2,3
1Centro de Química Estrutural, Institute of Molecular Sciences, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal.
Nutrients
|February 25, 2023
Summary
Natural compounds show promise for type 2 diabetes treatment. Researchers suggest focusing on polyphenol-carbohydrate combinations for safer, more effective functional nutrients and antidiabetic drugs.
Area of Science:
- Biochemistry
- Pharmacology
- Nutritional Science
Background:
- The type 2 diabetes epidemic necessitates novel therapeutic strategies.
- Natural polyphenols offer a promising avenue for developing antidiabetic compounds.
- Existing research on lipophilic polyphenols faces challenges due to low-quality reports and Pan-Assay Interference Compounds (PAINS).
Purpose of the Study:
- To critically evaluate the potential of natural polyphenols as a reliable source for antidiabetic drug discovery.
- To raise awareness regarding the limitations of current research on plant-derived antidiabetic compounds.
- To advocate for the development of polyphenol-carbohydrate combinations.
Main Methods:
- Evidence-based opinion article synthesizing current literature.
- Analysis of the structural properties and bioactivity of natural polyphenols.
- Consideration of the Pan-Assay Interference Compounds (PAINS) profile.
Main Results:
- Natural polyphenols, particularly when modified, hold significant potential for diabetes management.
- Lipophilic polyphenols exhibit membrane-perturbing properties that warrant careful consideration.
- The introduction of a C-glucosyl moiety may enhance the benefits of bioactive compounds.
Conclusions:
- A shift towards polyphenol-carbohydrate combinations is recommended for functional nutrient development.
- Early-stage antidiabetic drug discovery should prioritize compounds with improved safety and efficacy profiles.
- Further research into modified polyphenols could yield more reliable therapeutic leads for type 2 diabetes.
Keywords:
C-glucosylationPan-Assay Interference Compoundsfunctional nutrientsinvalid metabolic panaceasnatural product-based drug discoveryMore Related Videos
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