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Development of Nanoemulsions for Topical Application of Mupirocin

Bahjat Alhasso1, Muhammad Usman Ghori1, Barbara R Conway1,2

  • 1Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK.

Pharmaceutics
|February 25, 2023
PubMed

Insights

Nanoemulsions using eucalyptus oil or eucalyptol enhance topical delivery of the antibacterial mupirocin (MUP). These formulations show improved skin permeation and deposition, offering potential for managing skin infections.

Area of Science:

  • Pharmaceutical Sciences
  • Dermatology
  • Nanotechnology

Background:

  • Mupirocin (MUP) is a topical antibacterial agent for superficial skin infections.
  • Limited application of MUP is due to in vivo inactivation and plasma protein binding.
  • Nanoemulsion formulations can potentially enhance MUP delivery into the skin.

Purpose of the Study:

  • To prepare and characterize MUP-loaded nanoemulsions using eucalyptus oil (EO) or eucalyptol (EU).
  • To assess the potential of these nanoemulsions to enhance MUP skin delivery using an in vitro skin model.
  • To compare the efficacy of EO and EU based nanoemulsions for MUP delivery.

Main Methods:

  • MUP-loaded nanoemulsions were formulated using EO or EU as the oil phase, with Tween® 80 and Span® 80 as surfactant and cosurfactant.
  • Nanoemulsions were characterized for droplet size and particle size index (PDI).
  • In vitro skin permeation and deposition studies were conducted using an optimized skin model, comparing formulations to Bactroban® cream.

Main Results:

  • Optimized nanoemulsions (MUP-NE EO and MUP-NE EU) were successfully prepared.
  • MUP-NE EO exhibited smaller droplet size (35.89 ± 0.68 nm) and narrower PDI (0.10 ± 0.02) compared to MUP-NE EU.
  • Both nanoemulsions enhanced MUP transdermal permeation; EU-based nanoemulsion showed a two-fold increase, while EO-based nanoemulsion increased permeation by 48% compared to the control.
  • MUP-NE EU led to higher MUP detection in skin after 8 hours, whereas MUP-NE EO showed higher deposition after 24 hours.

Conclusions:

  • Nanoemulsion formulations using eucalyptus oil or eucalyptol can effectively enhance the topical delivery of mupirocin.
  • The choice of essential oil component (EO vs. EU) influences MUP permeation and skin deposition kinetics.
  • These findings suggest the potential for designing tailored nanoformulations for acute and prophylactic management of topical infections.
Keywords:
eucalyptoleucalyptus oilmupirocinnanoemulsionpermeationtopical delivery

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