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Updated: Aug 19, 2026
Spectral Confocal Imaging of Fluorescently tagged Nicotinic Receptors in Knock-in Mice with Chronic Nicotine Administration
Published on: February 10, 2012
The electrophysiological effects of nicotine in the rat cerebellum: evidence for direct postsynaptic actions
R de la Garza1, T J McGuire, R Freedman
1University of Colorado Health Sciences Center, Department of Pharmacology, Denver 80262.
Abstract:
The agonistic actions of nicotine in the cerebellum were dependent on the type of cerebellar neuron studied. Purkinje cells were inhibited and cerebellar interneurons were excited by pressure-ejected nicotine. The simultaneous iontophoresis of Mg2+ failed to block nicotine agonistic actions on either cell type. Since Mg2+ reduces presynaptic release of neurotransmitters, our findings suggest that the pharmacological actions of nicotine on cerebellar neurons are due to direct postsynaptic mechanisms.
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