Multi-Wavelength Photoacoustic Temperature Feedback Based Photothermal Therapy Method and System

Area of Science:

• Biomedical Engineering
• Optical Imaging
• Cancer Therapy

Background:

• Photothermal therapy (PTT) offers a noninvasive, repeatable tumor treatment alternative to radiation.
• Current PTT lacks accurate, real-time noninvasive temperature monitoring, leading to overtreatment and damage to surrounding healthy tissues.
• Precise temperature control is crucial for effective PTT and concurrent therapies.

Purpose of the Study:

• To develop and validate a multi-wavelength photoacoustic (PA) temperature feedback system for enhanced PTT.
• To improve the accuracy and safety of PTT by enabling real-time temperature measurement and control.
• To mitigate overtreatment and thermal damage to normal tissues during PTT.

Main Methods:

• Proposed a novel PTT method utilizing multi-wavelength photoacoustic (PA) thermometry for feedback control.
• Implemented a system where PA thermometry data at different wavelengths are cross-corrected.
• Regulated therapeutic light dose in real-time based on PA temperature feedback to control treatment temperature.

Main Results:

• The proposed PA temperature feedback system demonstrated real-time temperature measurement and control capabilities.
• Experimental results on swine blood samples confirmed high accuracy in temperature monitoring.
• Achieved temperature measurement accuracies of 0.56 °C and 0.68 °C, indicating effective control.

Conclusions:

• The multi-wavelength PA temperature feedback system significantly improves the accuracy and safety of PTT.
• This technology offers a promising solution for precise thermal management in PTT, reducing damage to healthy tissues.
• The system shows strong potential for clinical application in advanced cancer therapy.