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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Related Experiment Video

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Intra-lymph Node Injection of Biodegradable Polymer Particles
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PLGA Particles in Immunotherapy.

Dennis Horvath1,2, Michael Basler1,3

  • 1Division of Immunology, Department of Biology, University of Konstanz, D-78457 Konstanz, Germany.

Pharmaceutics
|February 25, 2023
PubMed
Summary
This summary is machine-generated.

Poly(lactic-co-glycolic acid) (PLGA) particles offer a safe and effective drug delivery platform for immunotherapy. These biodegradable particles protect therapeutic compounds, enabling targeted delivery and controlled release for treating various diseases.

Keywords:
PLGAantigen-delivery systemsbiodegradablecontrolled releasedrug repurposingimmunotherapymicroparticlesnanoparticlesvaccination

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Area of Science:

  • Biomaterials Science
  • Immunology
  • Drug Delivery Systems

Background:

  • Poly(lactic-co-glycolic acid) (PLGA) particles are approved drug delivery systems known for bioavailability, controlled release, and safety.
  • Immunotherapy is a potent treatment, but immunomodulating drugs require targeted delivery and are often rapidly eliminated.

Purpose of the Study:

  • To review recent advances in using particulate PLGA for immunotherapy.
  • To highlight PLGA particles as an ideal platform for targeted and sustained delivery of immunomodulating drugs.

Main Methods:

  • Literature review of recent studies on PLGA particles in immunotherapy.
  • Analysis of PLGA particle properties relevant to drug delivery for immune system modulation.

Main Results:

  • PLGA particles protect immunotherapeutic agents from degradation.
  • PLGA enables targeted delivery to specific immune cells and tissues.
  • Sustained and controlled release of drugs is achieved with PLGA particles.

Conclusions:

  • PLGA particles are a versatile platform for advancing immunotherapy.
  • Applications span allergy, autoimmunity, infectious diseases, and cancer treatment.
  • PLGA's properties are crucial for overcoming challenges in immunotherapy drug delivery.