Related Experiment Video
Updated: Aug 8, 2025
09:17
Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
Published on: February 28, 2025
384
Local Drug Delivery Strategies towards Wound Healing
1Pranveer Singh Institute of Technology (Pharmacy), Kanpur 208020, Uttar Pradesh, India.
Pharmaceutics
|February 25, 2023
Summary
This review explores wound healing, covering its physiology, treatments, and advanced local drug delivery systems. Enhanced delivery methods promise faster skin wound repair and regeneration.
Area of Science:
- Regenerative Medicine
- Dermatology
- Biomaterials Science
Background:
- Wound healing is a complex biological process integral to tissue regeneration and growth.
- It involves intricate cellular and matrix interactions to restore damaged tissue integrity.
- Understanding the physiology is key to developing effective therapeutic strategies.
Purpose of the Study:
- To review the physiology of wound healing.
- To examine current medications and treatments for wound healing.
- To explore local drug delivery systems for enhanced skin wound therapy.
Main Methods:
- Comprehensive literature review of wound healing physiology.
- Analysis of pharmacological agents used in wound treatment.
- Survey of diverse local drug delivery systems, including nanoparticles and hydrogels.
Main Results:
- Wound healing involves vascular response, coagulation, re-epithelialization, and tissue remodeling.
- Topical treatments include antiseptics, antibiotics, herbal remedies, and cellular initiators.
- Numerous advanced delivery systems like nanoparticles, hydrogels, and 3D printed replacements were identified.
Conclusions:
- Effective wound healing relies on managing infection and promoting tissue repair.
- Advanced antimicrobial strategies are crucial for eradicating infections and accelerating healing.
- Enhanced local drug delivery systems show significant potential for improving skin wound healing outcomes.
Related Concept Videos
01:22Drug Delivery: Miscellaneous Routes
426
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
426
01:16Drug Delivery: Overview
345
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
345
01:15Non-Oral Extravascular Drug Absorption Routes
259
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
259
01:29Drug Delivery: Parenteral Route
696
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
696
01:28Phases of Wound Repair
6.1K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
6.1K
01:18Drug Delivery: Enteral Route
559
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
559