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A Physiologically Based Pharmacokinetic Model of Ketoconazole and Its Metabolites as Drug-Drug Interaction

Fatima Zahra Marok1, Jan-Georg Wojtyniak1,2, Laura Maria Fuhr1

  • 1Clinical Pharmacy, Saarland University, 66123 Saarbruecken, Germany.

Pharmaceutics
|February 25, 2023
PubMed

Keywords:
P-glycoprotein (P-gp)cytochrome P450 3A4 (CYP3A4)drug–drug interactiondrug–food interactionketoconazolemetabolitesphysiologically based pharmacokinetic (PBPK) modelingreversible inhibition

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